A next-generation sequencing–based assay for minimal residual disease assessment in AML patients with FLT3-ITD mutations

Internal tandem duplications in fms-like tyrosine kinase 3 (FLT3-ITDs) are common in acute myeloid leukemia (AML) and confer a poor prognosis. A sensitive and specific assay for the detection of minimal residual disease (MRD) in FLT3-ITD mutated AML could guide therapy decisions. Existing assays for...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Levis, Mark J., Perl, Alexander E., Altman, Jessica K., Gocke, Christopher D., Bahceci, Erkut, Hill, Jason, Liu, Chaofeng, Xie, Zhiyi, Carson, Andrew R., McClain, Valerie, Stenzel, Timothy T., Miller, Jeffrey E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916006/
https://ncbi.nlm.nih.gov/pubmed/29643105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018015925
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