A Novel Tandem Duplication Assay to Detect Minimal Residual Disease in FLT3/ITD AML

BACKGROUND: Internal tandem duplication (ITD) of the FLT3 gene is associated with poor prognosis in acute myeloid leukemia (AML) patients with a normal karyotype. The current standard PCR assay for FLT3/ITD detection is not sufficiently sensitive to monitor minimal residual disease (MRD). Clone-spec...

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Gepubliceerd in:Mol Diagn Ther
Hoofdauteurs: Lin, Ming-Tseh, Tseng, Li-Hui, Dudley, Jonathan C., Riel, Stacey, Tsai, Harrison, Zheng, Gang, Pratz, Keith W., Levis, Mark J., Gocke, Christopher D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655128/
https://ncbi.nlm.nih.gov/pubmed/26446915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40291-015-0170-3
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