Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo

Acute myelogenous leukemia (AML) is the most common hematologic malignancy in adults, and is often associated with constitutive tyrosine kinase signaling. These pathways involve the non-receptor tyrosine kinases Fes, Syk and the three Src-family kinases expressed in myeloid cells (Fgr, Hck, and Lyn)...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Weir, Mark C., Shu, Sherry T., Patel, Ravi K., Hellwig, Sabine, Chen, Li, Tan, Li, Gray, Nathanael S., Smithgall, Thomas E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130198/
https://ncbi.nlm.nih.gov/pubmed/29763550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00154
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