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Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo

Acute myelogenous leukemia (AML) is the most common hematologic malignancy in adults, and is often associated with constitutive tyrosine kinase signaling. These pathways involve the non-receptor tyrosine kinases Fes, Syk and the three Src-family kinases expressed in myeloid cells (Fgr, Hck, and Lyn)...

詳細記述

保存先:
書誌詳細
出版年:ACS Chem Biol
主要な著者: Weir, Mark C., Shu, Sherry T., Patel, Ravi K., Hellwig, Sabine, Chen, Li, Tan, Li, Gray, Nathanael S., Smithgall, Thomas E.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130198/
https://ncbi.nlm.nih.gov/pubmed/29763550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00154
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