Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML

The FLT3-ITD mutation is one of the most prevalent oncogenic mutations in AML. Several FLT3 kinase inhibitors have shown impressive activity in clinical evaluation, however clinical responses are usually transient and clinical effects are rapidly lost due to drug resistance. One of the resistance me...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Wang, Aoli, Wu, Hong, Chen, Cheng, Hu, Chen, Qi, Ziping, Wang, Wenchao, Yu, Kailin, Liu, Xiaochuan, Zou, Fengming, Zhao, Zheng, Wu, Jiaxin, Liu, Juan, Liu, Feiyang, Wang, Li, Stone, Richard M., Galinksy, Ilene A., Griffin, James D., Zhang, Shanchun, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045383/
https://ncbi.nlm.nih.gov/pubmed/27074558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8675
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