Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML

The FLT3-ITD mutation is one of the most prevalent oncogenic mutations in AML. Several FLT3 kinase inhibitors have shown impressive activity in clinical evaluation, however clinical responses are usually transient and clinical effects are rapidly lost due to drug resistance. One of the resistance me...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Wang, Aoli, Wu, Hong, Chen, Cheng, Hu, Chen, Qi, Ziping, Wang, Wenchao, Yu, Kailin, Liu, Xiaochuan, Zou, Fengming, Zhao, Zheng, Wu, Jiaxin, Liu, Juan, Liu, Feiyang, Wang, Li, Stone, Richard M., Galinksy, Ilene A., Griffin, James D., Zhang, Shanchun, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045383/
https://ncbi.nlm.nih.gov/pubmed/27074558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8675
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