Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML

The FLT3-ITD mutation is one of the most prevalent oncogenic mutations in AML. Several FLT3 kinase inhibitors have shown impressive activity in clinical evaluation, however clinical responses are usually transient and clinical effects are rapidly lost due to drug resistance. One of the resistance me...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Wang, Aoli, Wu, Hong, Chen, Cheng, Hu, Chen, Qi, Ziping, Wang, Wenchao, Yu, Kailin, Liu, Xiaochuan, Zou, Fengming, Zhao, Zheng, Wu, Jiaxin, Liu, Juan, Liu, Feiyang, Wang, Li, Stone, Richard M., Galinksy, Ilene A., Griffin, James D., Zhang, Shanchun, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045383/
https://ncbi.nlm.nih.gov/pubmed/27074558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8675
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