Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

The SH2 domain of cytoplasmic tyrosine kinases can enhance catalytic activity and substrate recognition, but the molecular mechanisms by which this is achieved are poorly understood. We have solved the structure of the prototypic SH2-kinase unit of the human Fes tyrosine kinase, which appears specia...

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Detalhes bibliográficos
Main Authors: Filippakopoulos, Panagis, Kofler, Michael, Hantschel, Oliver, Gish, Gerald D., Grebien, Florian, Salah, Eidarus, Neudecker, Philipp, Kay, Lewis E., Turk, Benjamin E., Superti-Furga, Giulio, Pawson, Tony, Knapp, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572732/
https://ncbi.nlm.nih.gov/pubmed/18775312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.047
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