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The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR–ABL

The BCR–ABL fusion kinase is the driving mutation of chronic myelogenous leukemias and is also expressed in a subset of acute lymphoblastic leukemias. Recent advances in elucidating the structure, regulation, and signaling of BCR–ABL have led to the identification of allosteric sites that are distan...

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Main Authors: Hantschel, Oliver, Grebien, Florian, Superti-Furga, Giulio
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517953/
https://ncbi.nlm.nih.gov/pubmed/23002203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1276
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