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The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR–ABL

The BCR–ABL fusion kinase is the driving mutation of chronic myelogenous leukemias and is also expressed in a subset of acute lymphoblastic leukemias. Recent advances in elucidating the structure, regulation, and signaling of BCR–ABL have led to the identification of allosteric sites that are distan...

詳細記述

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書誌詳細
主要な著者: Hantschel, Oliver, Grebien, Florian, Superti-Furga, Giulio
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517953/
https://ncbi.nlm.nih.gov/pubmed/23002203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1276
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