Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

BACKGROUND: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity. The constitutively activated BCR/ABL-kinase “escapes” the auto-inhibi...

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Main Authors: Mian, Afsar Ali, Metodieva, Anna, Badura, Susanne, Khateb, Mamduh, Ruimi, Nili, Najajreh, Yousef, Ottmann, Oliver Gerhard, Mahajna, Jamal, Ruthardt, Martin
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488316/
https://ncbi.nlm.nih.gov/pubmed/22985168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-411
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