Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

BACKGROUND: Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors have been successfully established for the treatment of Ph (+) leukemias. Despite high rates of clinical response, Ph (+...

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Main Authors: Khateb, Mamduh, Ruimi, Nili, Khamisie, Hazem, Najajreh, Yousef, Mian, Afsar, Metodieva, Anna, Ruthardt, Martin, Mahajna, Jamal
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561207/
https://ncbi.nlm.nih.gov/pubmed/23186157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-563
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