CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells

Por Legut, Mateusz, Dolton, Garry, Mian, Afsar Ali, Ottmann, Oliver G., Sewell, Andrew K.
Publicado no Blood (2018)

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia

Por Mian, Afsar A., Metodieva, Anna, Najajreh, Yousef, Ottmann, Oliver G., Mahajna, Jamal, Ruthardt, Martin
Publicado em 2012

BCR: a new target in resistance mediated by BCR/ABL-315I?

Por Haberbosch, Isabella, Rafiei, Anahita, Oancea, Claudia, Ottmann, Gerhart Oliver, Ruthardt, Martin, Mian, Afsar Ali
Publicado no Genes Cancer (2016)

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

Por Khateb, Mamduh, Ruimi, Nili, Khamisie, Hazem, Najajreh, Yousef, Mian, Afsar, Metodieva, Anna, Ruthardt, Martin, Mahajna, Jamal
Publicado em 2012

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

Por Mian, Afsar Ali, Metodieva, Anna, Badura, Susanne, Khateb, Mamduh, Ruimi, Nili, Najajreh, Yousef, Ottmann, Oliver Gerhard, Mahajna, Jamal, Ruthardt, Martin
Publicado em 2012

The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome-Positive Acute Lymphatic Leukemia

Por Rafiei, Anahita, Mian, Afsar Ali, Döring, Claudia, Metodieva, Anna, Oancea, Claudia, Thalheimer, Frederic B., Hansmann, Martin Leo, Ottmann, Oliver Gerhard, Ruthardt, Martin
Publicado no PLoS Genet (2015)

STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML

Por Oancea, Claudia, Rüster, Brigitte, Brill, Boris, Roos, Jessica, Heinssmann, Maria, Bug, Gesine, Mian, Afsar Ali, Guillen, Nathalie Andrea, Kornblau, Steven M., Henschler, Reinhard, Ruthardt, Martin
Publicado no Genes Cancer (2014)