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Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity
Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukemia. Recent studies have indicated that an interaction between the SH2 domain and the N-lobe of the c-Abl kinase domain has a critical role in le...
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| Veröffentlicht in: | Biochem J |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5936049/ https://ncbi.nlm.nih.gov/pubmed/25779001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141492 |
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