Covalent Guanosine Mimetic Inhibitors of G12C KRAS

[Image: see text] Ras proteins are members of a large family of GTPase enzymes that are commonly mutated in cancer where they act as dominant oncogenes. We previously developed an irreversible guanosine-derived inhibitor, SML-8-73-1, of mutant G12C RAS that forms a covalent bond with cysteine 12. He...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Xiong, Yuan, Lu, Jia, Hunter, John, Li, Lianbo, Scott, David, Choi, Hwan Geun, Lim, Sang Min, Manandhar, Anuj, Gondi, Sudershan, Sim, Taebo, Westover, Kenneth D., Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238463/
https://ncbi.nlm.nih.gov/pubmed/28105276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00373
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