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Structural dynamics in Ras and related proteins upon nucleotide switching

Structural dynamics of Ras proteins contribute to their activity in signal transduction cascades. Directly targeting Ras proteins with small molecules may rely on movement of a conserved structural motif, switch II. To understand Ras signaling and advance Ras targeting strategies, experimental metho...

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Bibliografski detalji
Izdano u:J Mol Biol
Glavni autori: Harrison, Rane A., Lu, Jia, Carrasco, Martin, Hunter, John, Manandhar, Anuj, Gondi, Sudershan, Westover, Kenneth D., Engen, John R.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661953/
https://ncbi.nlm.nih.gov/pubmed/27751724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.10.017
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