Structural dynamics in Ras and related proteins upon nucleotide switching

Structural dynamics of Ras proteins contribute to their activity in signal transduction cascades. Directly targeting Ras proteins with small molecules may rely on movement of a conserved structural motif, switch II. To understand Ras signaling and advance Ras targeting strategies, experimental metho...

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Udgivet i:J Mol Biol
Main Authors: Harrison, Rane A., Lu, Jia, Carrasco, Martin, Hunter, John, Manandhar, Anuj, Gondi, Sudershan, Westover, Kenneth D., Engen, John R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661953/
https://ncbi.nlm.nih.gov/pubmed/27751724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.10.017
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