Ras Conformational Switching: Simulating Nucleotide-Dependent Conformational Transitions with Accelerated Molecular Dynamics

Ras mediates signaling pathways controlling cell proliferation and development by cycling between GTP- and GDP-bound active and inactive conformational states. Understanding the complete reaction path of this conformational change and its intermediary structures is critical to understanding Ras sign...

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Bibliographic Details
Main Authors: Grant, Barry J., Gorfe, Alemayehu A., McCammon, J. Andrew
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651530/
https://ncbi.nlm.nih.gov/pubmed/19300489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000325
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