Conformational Selection in G-Proteins: Lessons from Ras and Rho

The induced fit model has traditionally been invoked to describe the activating conformational change of the monomeric G-proteins, such as Ras and Rho. With this scheme, the presence or absence of the γ-phosphate of GTP leads to an instantaneous switch in conformation. Here we describe atomistic mol...

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Bibliografiske detaljer
Main Authors: Grant, Barry J., McCammon, J. Andrew, Gorfe, Alemayehu A.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2010
Fag:
Biophysical Letter
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998626/
https://ncbi.nlm.nih.gov/pubmed/21112273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.020
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