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The Distinct Conformational Dynamics of K-Ras and H-Ras A59G

Ras proteins regulate signaling cascades crucial for cell proliferation and differentiation by switching between GTP- and GDP-bound conformations. Distinct Ras isoforms have unique physiological functions with individual isoforms associated with different cancers and developmental diseases. Given th...

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Main Authors: Lukman, Suryani, Grant, Barry J., Gorfe, Alemayehu A., Grant, Guy H., McCammon, J. Andrew
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936511/
https://ncbi.nlm.nih.gov/pubmed/20838576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000922
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