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Mapping the nucleotide and isoform dependent structural and dynamical features of Ras proteins
Ras GTPases are conformational switches controlling cell proliferation, differentiation and development. Despite their prominent role in many forms of cancer, the mechanism of conformational transition between inactive GDP- and active GTP-bound states remains unclear. Here we describe a detailed ana...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519881/ https://ncbi.nlm.nih.gov/pubmed/18547521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.03.009 |
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