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GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRAS(P34R)
RAS proteins are commonly mutated in cancerous tumors, but germline RAS mutations are also found in RASopathy syndromes such as Noonan syndrome (NS) and cardiofaciocutaneous (CFC) syndrome. Activating RAS mutations can be subclassified based on their activating mechanisms. Understanding the structur...
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| Publicado no: | Birth Defects Res |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7495839/ https://ncbi.nlm.nih.gov/pubmed/32187889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdr2.1647 |
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