Kras(P34R) and Kras(T58I) mutations induce distinct RASopathy phenotypes in mice

Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of germline KRAS mutations causes developmental disorders called RASopathies. The mutant proteins encoded by these germline KRAS mutations are less biochemically and functionally activated than those in can...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wong, Jasmine C., Perez-Mancera, Pedro A., Huang, Tannie Q., Kim, Jangkyung, Grego-Bessa, Joaquim, del pilar Alzamora, Maria, Kogan, Scott C., Sharir, Amnon, Keefe, Susan H., Morales, Carolina E., Schanze, Denny, Castel, Pau, Hirose, Kentaro, Huang, Guo N., Zenker, Martin, Sheppard, Dean, Klein, Ophir D., Tuveson, David A., Braun, Benjamin S., Shannon, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710308/
https://ncbi.nlm.nih.gov/pubmed/32990679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140495
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