Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4)

Interleukin-1 receptor–associated kinase 4 (IRAK4) is a key player in innate immune and inflammatory responses, performing a critical role in signal transduction downstream of Toll-like receptors and interleukin-1 (IL-1) receptors. Upon ligand binding and via its N-terminal death domain, IRAK4 is re...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Li, Ferrao, Ryan, Li, Qiubai, Hatcher, John M., Choi, Hwan Geun, Buhrlage, Sara J., Gray, Nathanael S., Wu, Hao
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433055/
https://ncbi.nlm.nih.gov/pubmed/30679311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005428
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