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IRAK4 Dimerization and Trans-autophosphorylation are Induced by Myddosome Assembly

Trans -autophosphorylation is among the most prevalent means of protein kinase activation, yet its molecular basis is poorly defined. In Toll-like receptor and interleukin-1 receptor signaling pathways, the kinase IRAK4 is recruited to the membrane proximal adapter MyD88 through death domain (DD) in...

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Détails bibliographiques
Auteurs principaux: Ferrao, Ryan, Zhou, Hao, Shan, Yibing, Li, Qiubai, Shaw, David E., Li, Xiaoxia, Wu, Hao
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169746/
https://ncbi.nlm.nih.gov/pubmed/25201411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.006
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