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The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold
Activation of Toll-like receptors induces dimerization and the recruitment of the death domain (DD) adaptor protein MyD88 into an oligomeric post receptor complex termed the Myddosome. The Myddosome is a hub for inflammatory and oncogenic signaling and has a hierarchical arrangement with 6–8 MyD88 m...
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Publicado no: | Sci Rep |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5120336/ https://ncbi.nlm.nih.gov/pubmed/27876844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37267 |
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