The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

We have developed the first assays that measure the protein kinase activities of interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4 reliably in human cell extracts, by employing Pellino1 as a substrate in conjunction with specific pharmacological inhibitors of IRAK1 and IRAK4. We exploited...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Vollmer, Stefan, Strickson, Sam, Zhang, Tinghu, Gray, Nathanael, Lee, Katherine L., Rao, Vikram R., Cohen, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460469/
https://ncbi.nlm.nih.gov/pubmed/28512203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170097
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