The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

Eitemau Tebyg

• Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling
  gan: De Nardo, Dominic, et al.
  Cyhoeddwyd: (2018)
• Paired toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12
  gan: Zheng, Rongxiu, et al.
  Cyhoeddwyd: (2008)
• Toll-Like Receptor Signaling Licenses IRAK1 For Rapid Activation Of The NLRP3 Inflammasome
  gan: Fernandes-Alnemri, Teresa, et al.
  Cyhoeddwyd: (2013)
• Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation
  gan: Conze, Dietrich B., et al.
  Cyhoeddwyd: (2008)
• IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes
  gan: Cushing, Leah, et al.
  Cyhoeddwyd: (2017)