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Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation

Stimulation through the interleukin-1 receptor (IL-1R) and some Toll-like receptors (TLRs) induces ubiquitination of TRAF6 and IRAK-1, signaling components required for NF-κB and mitogen-activated protein kinase activation. Here we show that although TRAF6 and IRAK-1 acquired Lys63 (K63)-linked poly...

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Bibliografiske detaljer
Main Authors: Conze, Dietrich B., Wu, Chuan-Jin, Thomas, James A., Landstrom, Allison, Ashwell, Jonathan D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423148/
https://ncbi.nlm.nih.gov/pubmed/18347055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02098-07
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