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The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys(63)-linked polyubiquitination of IRAK1

The protein kinases IRAK [IL-1 (interleukin 1) receptor-associated kinase] 1 and 4 play key roles in a signalling pathway by which bacterial infection or IL-1 trigger the production of inflammatory mediators. In the present study, we demonstrate that IRAK1 and IRAK4 phosphorylate Pellino isoforms in...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Biochem J
Päätekijät: Ordureau, Alban, Smith, Hilary, Windheim, Mark, Peggie, Mark, Carrick, Emma, Morrice, Nick, Cohen, Philip
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791886/
https://ncbi.nlm.nih.gov/pubmed/17997719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20071365
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