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Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys‐48 and ‐63

Proteins tagged with lysine (Lys, K) 48 polyubiquitins chains are destined for degradation by the 26S proteasomal system. Impairment of the ubiquitin proteasome system (UPS) function culminates in the accumulation of polyubiquitinated proteins in many neurodegenerative conditions including Parkinson...

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Bibliografski detalji
Glavni autori: Sun, Faneng, Kanthasamy, Arthi, Anantharam, Vellareddy, Kanthasamy, Anumantha G.
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819597/
https://ncbi.nlm.nih.gov/pubmed/19432818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00775.x
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