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Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys‐48 and ‐63

Proteins tagged with lysine (Lys, K) 48 polyubiquitins chains are destined for degradation by the 26S proteasomal system. Impairment of the ubiquitin proteasome system (UPS) function culminates in the accumulation of polyubiquitinated proteins in many neurodegenerative conditions including Parkinson...

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Bibliografiske detaljer
Main Authors: Sun, Faneng, Kanthasamy, Arthi, Anantharam, Vellareddy, Kanthasamy, Anumantha G.
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819597/
https://ncbi.nlm.nih.gov/pubmed/19432818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00775.x
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