Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease

BACKGROUND: In previous work, we investigated dieldrin cytotoxicity and signaling cell death mechanisms in dopaminergic PC12 cells. Dieldrin has been reported to be one of the environmental factors correlated with Parkinson's disease and may selectively destroy dopaminergic neurons. METHODS: He...

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Detalhes bibliográficos
Main Authors: Kanthasamy, Anumantha G, Kitazawa, Masashi, Yang, Yongjie, Anantharam, Vellareddy, Kanthasamy, Arthi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584097/
https://ncbi.nlm.nih.gov/pubmed/18945348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-1-12
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