ENVIRONMENTAL NEUROTOXIC PESTICIDE DIELDRIN ACTIVATES A NON RECEPTOR TYROSINE KINASE TO PROMOTE PKCδ-MEDIATED DOPAMINERGIC APOPTOSIS IN A DOPAMINERGIC NEURONAL CELL MODEL

Oxidative stress and apoptosis are two key pathophysiological mechanisms underlying dopaminergic degeneration in Parkinson’s disease (PD). Recently, we identified that proteolytic activation of protein kinase C-delta (PKCδ), a member of the novel PKC family, contributes to oxidative stress-induced d...

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Hauptverfasser: Kanthasamy, Anumantha G., Saminathan, Hariharan, Asaithambi, Arunkumar, Anantharam, Vellareddy, Kanthasamy, Arthi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328137/
https://ncbi.nlm.nih.gov/pubmed/21801747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2011.06.009
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