Methamphetamine-induced neurotoxicity linked to UPS dysfunction and autophagy related changes that can be modulated by PKCδ in dopaminergic neuronal cells

A compromised protein degradation machinery has been implicated in methamphetamine (MA)-induced neurodegeneration. However, the signaling mechanisms that induce autophagy and UPS dysfunction are not well understood. The present study investigates the contributions of PKC delta (PKCδ) mediated signal...

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Autori principali: Lin, Mengshien, Shivalingappa, Prashanth Chandramani, Jin, Huajun, Ghosh, Anamitra, Anantharam, Vellareddy, Ali, Syed, Kanthasamy, Anumantha G., Kanthasamy, Arthi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358550/
https://ncbi.nlm.nih.gov/pubmed/22445524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.03.004
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