Toll-Like Receptor Signaling Licenses IRAK1 For Rapid Activation Of The NLRP3 Inflammasome

Activation of the NLRP3 inflammasome by diverse stimuli requires a priming signal from Toll-like receptors (TLRs) and an activation signal from purinergic receptors or pore-forming toxins. Here we demonstrate through detailed analysis of NLRP3 activation in macrophages deficient in key downstream TL...

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Bibliographic Details
Main Authors: Fernandes-Alnemri, Teresa, Kang, Seokwon, Anderson, Connor, Sagara, Junji, Fitzgerald, Katherine A., Alnemri, Emad S.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924784/
https://ncbi.nlm.nih.gov/pubmed/24043892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301681
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