Discovery of a BTK/MNK Dual Inhibitor for Lymphoma and Leukemia

BTK kinase is a member of the TEC kinase family and is a key regulator of the B-cell Receptor (BCR)-mediated signaling pathway. It is important for B-cell maturation, proliferation, survival and metastasis. Pharmacological inhibition of BTK is clinically effective against a variety of B-cell maligna...

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Dades bibliogràfiques
Publicat a:Leukemia
Autors principals: Wu, Hong, Hu, Chen, Wang, Aoli, Weisberg, Ellen L., Chen, Yongfei, Yun, Cai-Hong, Wang, Wenchao, Liu, Yan, Liu, Xiaochuan, Tian, Bei, Wang, Jinhua, Zhao, Zheng, Liang, Yanke, Li, Binhua, Wang, Li, Wang, Beilei, Chen, Cheng, Buhrlage, Sara J., Nonami, Atsushi, Li, Yuyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Wang, Xianhuo, Yang, Guang, Griffin, James D., Brown, Jennifer R., Eck, Michael J., Liu, Jing, Gray, Nathanael S., Liu, Qingsong
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987129/
https://ncbi.nlm.nih.gov/pubmed/26165234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.180
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