Discovery of a BTK/MNK Dual Inhibitor for Lymphoma and Leukemia

BTK kinase is a member of the TEC kinase family and is a key regulator of the B-cell Receptor (BCR)-mediated signaling pathway. It is important for B-cell maturation, proliferation, survival and metastasis. Pharmacological inhibition of BTK is clinically effective against a variety of B-cell maligna...

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Publicado no:Leukemia
Main Authors: Wu, Hong, Hu, Chen, Wang, Aoli, Weisberg, Ellen L., Chen, Yongfei, Yun, Cai-Hong, Wang, Wenchao, Liu, Yan, Liu, Xiaochuan, Tian, Bei, Wang, Jinhua, Zhao, Zheng, Liang, Yanke, Li, Binhua, Wang, Li, Wang, Beilei, Chen, Cheng, Buhrlage, Sara J., Nonami, Atsushi, Li, Yuyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Wang, Xianhuo, Yang, Guang, Griffin, James D., Brown, Jennifer R., Eck, Michael J., Liu, Jing, Gray, Nathanael S., Liu, Qingsong
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987129/
https://ncbi.nlm.nih.gov/pubmed/26165234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.180
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