Discovery of a BTK/MNK Dual Inhibitor for Lymphoma and Leukemia

BTK kinase is a member of the TEC kinase family and is a key regulator of the B-cell Receptor (BCR)-mediated signaling pathway. It is important for B-cell maturation, proliferation, survival and metastasis. Pharmacological inhibition of BTK is clinically effective against a variety of B-cell maligna...

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Bibliografske podrobnosti
izdano v:Leukemia
Main Authors: Wu, Hong, Hu, Chen, Wang, Aoli, Weisberg, Ellen L., Chen, Yongfei, Yun, Cai-Hong, Wang, Wenchao, Liu, Yan, Liu, Xiaochuan, Tian, Bei, Wang, Jinhua, Zhao, Zheng, Liang, Yanke, Li, Binhua, Wang, Li, Wang, Beilei, Chen, Cheng, Buhrlage, Sara J., Nonami, Atsushi, Li, Yuyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Wang, Xianhuo, Yang, Guang, Griffin, James D., Brown, Jennifer R., Eck, Michael J., Liu, Jing, Gray, Nathanael S., Liu, Qingsong
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987129/
https://ncbi.nlm.nih.gov/pubmed/26165234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.180
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