Discovery of a BTK/MNK Dual Inhibitor for Lymphoma and Leukemia

BTK kinase is a member of the TEC kinase family and is a key regulator of the B-cell Receptor (BCR)-mediated signaling pathway. It is important for B-cell maturation, proliferation, survival and metastasis. Pharmacological inhibition of BTK is clinically effective against a variety of B-cell maligna...

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Gepubliceerd in:Leukemia
Hoofdauteurs: Wu, Hong, Hu, Chen, Wang, Aoli, Weisberg, Ellen L., Chen, Yongfei, Yun, Cai-Hong, Wang, Wenchao, Liu, Yan, Liu, Xiaochuan, Tian, Bei, Wang, Jinhua, Zhao, Zheng, Liang, Yanke, Li, Binhua, Wang, Li, Wang, Beilei, Chen, Cheng, Buhrlage, Sara J., Nonami, Atsushi, Li, Yuyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Wang, Xianhuo, Yang, Guang, Griffin, James D., Brown, Jennifer R., Eck, Michael J., Liu, Jing, Gray, Nathanael S., Liu, Qingsong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987129/
https://ncbi.nlm.nih.gov/pubmed/26165234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.180
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