Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances

PI3Kδ is predominately expressed in leukocytes and has been found overexpressed in B-cell related malignances such as CLL and AML. We have discovered a highly selective ATP competitive PI3Kd inhibitor PI3KD-IN-015, which exhibits a high selectivity among other PI3K isoforms in both biochemical assay...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Xiaochuan, Wang, Aoli, Liang, Xiaofei, Chen, Cheng, Liu, Juanjuan, Zhao, Zheng, Wu, Hong, Deng, Yuanxin, Wang, Li, Wang, Beilei, Wu, Jiaxin, Liu, Feiyang, Fernandes, Stacey M., Adamia, Sophia, Stone, Richard M., Galinsky, Ilene A., Brown, Jennifer R., Griffin, James D., Zhang, Shanchun, Loh, Teckpeng, Zhang, Xin, Wang, Wenchao, Weisberg, Ellen L., Liu, Jing, Liu, Qingsong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078040/
https://ncbi.nlm.nih.gov/pubmed/27081697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8702
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