Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model

BTK plays a critical role in the B cell receptor mediated inflammatory signaling in the rheumatoid arthritis (RA). Through a rational design approach we discovered a highly selective and potent BTK kinase inhibitor (CHMFL-BTK-11) which exerted its inhibitory efficacy through a covalent bond with BTK...

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Publicado no:Sci Rep
Main Authors: Wu, Hong, Huang, Qiong, Qi, Ziping, Chen, Yongfei, Wang, Aoli, Chen, Cheng, Liang, Qianmao, Wang, Jinghua, Chen, Wensheng, Dong, Jin, Yu, Kailin, Hu, Chen, Wang, Wenchao, Liu, Xiaochuan, Deng, Yuanxin, Wang, Li, Wang, Beilei, Li, Xiaoxiang, Gray, Nathanael S., Liu, Jing, Wei, Wei, Liu, Qingsong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428509/
https://ncbi.nlm.nih.gov/pubmed/28352114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00482-4
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