Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent

Angiogenesis is an essential process in tumor growth, invasion and metastasis. VEGF receptor 2 (VEGFR2) inhibitors targeting tumor angiogenic pathway have been widely used in the clinical cancer treatment. However, most of currently used VEGFR2 kinase inhibitors are multi-target inhibitors which mig...

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Bibliographische Detailangaben
Veröffentlicht in:Acta Pharm Sin B
Hauptverfasser: Jiang, Zongru, Wang, Li, Liu, Xuesong, Chen, Cheng, Wang, Beilei, Wang, Wenliang, Hu, Chen, Yu, Kailin, Qi, Ziping, Liu, Qingwang, Wang, Aoli, Liu, Jing, Hong, Guangchen, Wang, Wenchao, Liu, Qingsong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049616/
https://ncbi.nlm.nih.gov/pubmed/32140394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.10.004
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