Hydrogen/Deuterium Exchange Mass Spectrometry for Probing Higher Order Structure of Protein Therapeutics: Methodology and Applications

The higher order structure of protein therapeutics can be interrogated with hydrogen/deuterium exchange mass spectrometry (HDX-MS). HDX-MS is now a widely used tool in the structural characterization of protein therapeutics. In this article, HDX-MS based workflows designed for both protein therapeut...

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Bibliografiske detaljer
Main Authors: Wei, Hui, Mo, Jingjie, Tao, Li, Russell, Reb J., Tymiak, Adrienne A., Chen, Guodong, Iacob, Roxana E., Engen, John R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081482/
https://ncbi.nlm.nih.gov/pubmed/23928097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2013.07.019
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