Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors

[Image: see text] Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. We developed and performed a cellular high-throughput screen for inhibitors of Wnt secretion and pathway activation. A lead structure (GNF-1331) was identified from the screen. Further stu...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Cheng, Dai, Liu, Jun, Han, Dong, Zhang, Guobao, Gao, Wenqi, Hsieh, Mindy H., Ng, Nicholas, Kasibhatla, Shailaja, Tompkins, Celin, Li, Jie, Steffy, Auzon, Sun, Fangxian, Li, Chun, Seidel, H. Martin, Harris, Jennifer L., Pan, Shifeng
Format: Artigo
Language:Inglês
Published: American Chemical Society 2016
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948009/
https://ncbi.nlm.nih.gov/pubmed/27437076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00038
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