Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus

[Image: see text] A high-throughput screen based on a viral replication assay was used to identify inhibitors of the human cytomegalovirus. Using this approach, hit compound 1 was identified as a 4 μM inhibitor of HCMV that was specific and selective over other herpes viruses. Time of addition studi...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Fader, Lee, Brault, Martine, Desjardins, Jessica, Dansereau, Nathalie, Lamorte, Louie, Tremblay, Sonia, Bilodeau, François, Bordeleau, Josée, Duplessis, Martin, Gorys, Vida, Gillard, James, Gleason, James L., James, Clint, Joly, Marc-André, Kuhn, Cyrille, Llinas-Brunet, Montse, Luo, Laibin, Morency, Louis, Morin, Sébastien, Parisien, Mathieu, Poirier, Maude, Thibeault, Carl, Trinh, Thao, Sturino, Claudio, Srivastava, Sanjay, Yoakim, Christiane, Franti, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867477/
https://ncbi.nlm.nih.gov/pubmed/27190604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00064
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