In Vitro Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335

The in vitro resistance profile of BI 201335 was evaluated through selection and characterization of variants in genotype 1a (GT 1a) and genotype 1b (GT 1b) replicons. NS3 R155K and D168V were the most frequently observed resistant variants. Phenotypic characterization of the mutants revealed shifts...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lagacé, Lisette, White, Peter W., Bousquet, Christiane, Dansereau, Nathalie, Dô, Florence, Llinas-Brunet, Montse, Marquis, Martin, Massariol, Marie-Josée, Maurice, Roger, Spickler, Catherine, Thibeault, Diane, Triki, Ibtissem, Zhao, Songping, Kukolj, George
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256085/
https://ncbi.nlm.nih.gov/pubmed/22024816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05166-11
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky