In Vitro Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335

The in vitro resistance profile of BI 201335 was evaluated through selection and characterization of variants in genotype 1a (GT 1a) and genotype 1b (GT 1b) replicons. NS3 R155K and D168V were the most frequently observed resistant variants. Phenotypic characterization of the mutants revealed shifts...

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Detalhes bibliográficos
Main Authors: Lagacé, Lisette, White, Peter W., Bousquet, Christiane, Dansereau, Nathalie, Dô, Florence, Llinas-Brunet, Montse, Marquis, Martin, Massariol, Marie-Josée, Maurice, Roger, Spickler, Catherine, Thibeault, Diane, Triki, Ibtissem, Zhao, Songping, Kukolj, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256085/
https://ncbi.nlm.nih.gov/pubmed/22024816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05166-11
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