In Vitro Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335

The in vitro resistance profile of BI 201335 was evaluated through selection and characterization of variants in genotype 1a (GT 1a) and genotype 1b (GT 1b) replicons. NS3 R155K and D168V were the most frequently observed resistant variants. Phenotypic characterization of the mutants revealed shifts...

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Main Authors: Lagacé, Lisette, White, Peter W., Bousquet, Christiane, Dansereau, Nathalie, Dô, Florence, Llinas-Brunet, Montse, Marquis, Martin, Massariol, Marie-Josée, Maurice, Roger, Spickler, Catherine, Thibeault, Diane, Triki, Ibtissem, Zhao, Songping, Kukolj, George
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256085/
https://ncbi.nlm.nih.gov/pubmed/22024816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05166-11
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