Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance

Although optimizing the resistance profile of an inhibitor can be challenging, it is potentially important for improving the long term effectiveness of antiviral therapy. This work describes our rational approach toward the identification of a macrocyclic acylsulfonamide that is a potent inhibitor o...

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Bibliografiska uppgifter
Huvudupphovsmän: O'Meara, Jeff A., Lemke, Christopher T., Godbout, Cédrickx, Kukolj, George, Lagacé, Lisette, Moreau, Benoît, Thibeault, Diane, White, Peter W., Llinàs-Brunet, Montse
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581377/
https://ncbi.nlm.nih.gov/pubmed/23271737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439455
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