Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance

Although optimizing the resistance profile of an inhibitor can be challenging, it is potentially important for improving the long term effectiveness of antiviral therapy. This work describes our rational approach toward the identification of a macrocyclic acylsulfonamide that is a potent inhibitor o...

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מידע ביבליוגרפי
Main Authors: O'Meara, Jeff A., Lemke, Christopher T., Godbout, Cédrickx, Kukolj, George, Lagacé, Lisette, Moreau, Benoît, Thibeault, Diane, White, Peter W., Llinàs-Brunet, Montse
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
נושאים:
Molecular Bases of Disease
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581377/
https://ncbi.nlm.nih.gov/pubmed/23271737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439455
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