Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors

Por Cheng, Dai, Liu, Jun, Han, Dong, Zhang, Guobao, Gao, Wenqi, Hsieh, Mindy H., Ng, Nicholas, Kasibhatla, Shailaja, Tompkins, Celin, Li, Jie, Steffy, Auzon, Sun, Fangxian, Li, Chun, Seidel, H. Martin, Harris, Jennifer L., Pan, Shifeng
Publicado no ACS Med Chem Lett (2016)

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Por Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Phung, Van, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Wu, Xu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.
Publicado em 2013