Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in Vivo

Por Ning, Yun, Schuller, Alwin G. P., Conover, Cheryl A., Pintar, John E.
Publicado em 2008

AZ1366: An inhibitor of tankyrase and the canonical Wnt pathway that limits the persistence of non-small cell lung cancer cells following EGFR inhibition

Por Scarborough, Hannah A, Helfrich, Barbara A, Casás-Selves, Matias, Schuller, Alwin G, Grosskurth, Shaun E, Kim, Jihye, Tan, Aik-Choon, Chan, Daniel C, Zhang, Zhiyong, Zaberezhnyy, Vadym, Bunn, Paul A, DeGregori, James
Publicado no Clin Cancer Res (2016)

Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation

Por Henry, Ryan E., Barry, Evan R., Castriotta, Lillian, Ladd, Brendon, Markovets, Aleksandra, Beran, Garry, Ren, Yongxin, Zhou, Feng, Adam, Ammar, Zinda, Michael, Reimer, Corinne, Qing, Weiguo, Su, Weiguo, Clark, Edwin, D'Cruz, Celina M., Schuller, Alwin G.
Publicado no Oncotarget (2016)

The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance

Por Quackenbush, Kevin S., Bagby, Stacey, Tai, Wai Meng, Messersmith, Wells A., Schreiber, Anna, Greene, Justin, Kim, Jihye, Wang, Guoliang, Purkey, Alicia, Pitts, Todd M., Nguyen, Anna, Gao, Dexiang, Blatchford, Patrick, Capasso, Anna, Schuller, Alwin G., Eckhardt, S. Gail, Arcaroli, John J.
Publicado no Oncotarget (2016)

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

Por Ettenberg, Seth A., Charlat, Olga, Daley, Michael P., Liu, Shanming, Vincent, Karen J., Stuart, Darrin D., Schuller, Alwin G., Yuan, Jing, Ospina, Beatriz, Green, John, Yu, Qunyan, Walsh, Renee, Li, Sharon, Schmitz, Rita, Heine, Holger, Bilic, Sanela, Ostrom, Lance, Mosher, Rebecca, Hartlepp, K. Felix, Zhu, Zhenping, Fawell, Stephen, Yao, Yung-Mae, Stover, David, Finan, Peter M., Porter, Jeffery A., Sellers, William R., Klagge, Ingo M., Cong, Feng
Publicado em 2010

MCL1 and BCL-xL Levels in Solid Tumors Are Predictive of Dinaciclib-Induced Apoptosis

Por Booher, Robert N., Hatch, Harold, Dolinski, Brian M., Nguyen, Thi, Harmonay, Lauren, Al-Assaad, Ali-Samer, Ayers, Mark, Nebozhyn, Michael, Loboda, Andrey, Hirsch, Heather A., Zhang, Theresa, Shi, Bin, Merkel, Carrie E., Angagaw, Minilik H., Wang, Yaolin, Long, Brian J., Lennon, Xianlu Q., Miselis, Nathan, Pucci, Vincenzo, Monahan, James W., Lee, Junghoon, Kondic, Anna Georgieva, Im, Eun Kyung, Mauro, David, Blanchard, Rebecca, Gilliland, Gary, Fawell, Stephen E., Zawel, Leigh, Schuller, Alwin G., Strack, Peter
Publicado em 2014

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Por Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Phung, Van, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Wu, Xu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.
Publicado em 2013