A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit

Por Kopinja, Johnny, Sevilla, Raquel S., Levitan, Diane, Dai, David, Vanko, Amy, Spooner, Edward, Ware, Chris, Forget, Robert, Hu, Kun, Kral, Astrid, Spacciapoli, Peter, Kennan, Richard, Jayaraman, Lata, Pucci, Vincenzo, Perera, Samanthi, Zhang, Weisheng, Fischer, Christian, Lam, Michael H.
Publicado no Sci Rep (2017)

The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

Por Pokorny, Jenny L., Calligaris, David, Gupta, Shiv K., Iyekegbe, Dennis O., Mueller, Dustin, Bakken, Katrina K., Carlson, Brett L., Schroeder, Mark A., Evans, Debra L., Lou, Zhenkun, Decker, Paul A., Eckel-Passow, Jeanette E., Pucci, Vincenzo, Ma, Bennett, Shumway, Stuart D., Elmquist, William, Agar, Nathalie Y., Sarkaria, Jann N.
Publicado no Clin Cancer Res (2015)

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Por Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Di Filippo, Marcello, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Publicado em 2012

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Por Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Filippo, Marcello Di, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., Huang, Qian, McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Publicado em 2014

Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia

Por Liu, Ping, Wang, Liping, DuBois, Byron G., Colandrea, Vincent J., Liu, Rongqiang, Cai, Jiaqiang, Du, Xiaoxing, Quan, Weiguo, Morris, William, Bai, Jianwu, Bishwokarma, Bimjhana, Cheng, Mangeng, Piesvaux, Jennifer, Ray, Kallol, Alpert, Carla, Chiu, Chi-Sung, Zielstorff, Mark, Metzger, Joseph M., Yang, Liming, Leung, Dennis, Alleyne, Candice, Vincent, Stella H., Pucci, Vincenzo, Li, Xiaofang, Crespo, Alejandro, Stickens, Dominique, Hale, Jeffrey J., Ujjainwalla, Feroze, Sinz, Christopher J.
Publicado no ACS Med Chem Lett (2018)

MCL1 and BCL-xL Levels in Solid Tumors Are Predictive of Dinaciclib-Induced Apoptosis

Por Booher, Robert N., Hatch, Harold, Dolinski, Brian M., Nguyen, Thi, Harmonay, Lauren, Al-Assaad, Ali-Samer, Ayers, Mark, Nebozhyn, Michael, Loboda, Andrey, Hirsch, Heather A., Zhang, Theresa, Shi, Bin, Merkel, Carrie E., Angagaw, Minilik H., Wang, Yaolin, Long, Brian J., Lennon, Xianlu Q., Miselis, Nathan, Pucci, Vincenzo, Monahan, James W., Lee, Junghoon, Kondic, Anna Georgieva, Im, Eun Kyung, Mauro, David, Blanchard, Rebecca, Gilliland, Gary, Fawell, Stephen E., Zawel, Leigh, Schuller, Alwin G., Strack, Peter
Publicado em 2014

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Por Harper, Steven, McCauley, John A., Rudd, Michael T., Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W., Romano, Joseph J., Bush, Kimberly J., Gilbert, Kevin F., McIntyre, Charles J., Nguyen, Kevin T., Nizi, Emanuela, Carroll, Steven S., Ludmerer, Steven W., Burlein, Christine, DiMuzio, Jillian M., Graham, Donald J., McHale, Carolyn M., Stahlhut, Mark W., Olsen, David B., Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M., Rowley, Michael, Coleman, Paul J., Vacca, Joseph P., Summa, Vincenzo, Liverton, Nigel J.
Publicado em 2012