The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

PURPOSE: Wee1 regulates key DNA damage checkpoints, and in this study, the efficacy of the Wee1 inhibitor MK-1775 was evaluated in GBM xenograft models alone and in combination with radiation and/or temozolomide (TMZ). EXPERIMENTAL DESIGN: In vitro MK-1775 efficacy alone and in combination with TMZ,...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Pokorny, Jenny L., Calligaris, David, Gupta, Shiv K., Iyekegbe, Dennis O., Mueller, Dustin, Bakken, Katrina K., Carlson, Brett L., Schroeder, Mark A., Evans, Debra L., Lou, Zhenkun, Decker, Paul A., Eckel-Passow, Jeanette E., Pucci, Vincenzo, Ma, Bennett, Shumway, Stuart D., Elmquist, William, Agar, Nathalie Y., Sarkaria, Jann N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401631/
https://ncbi.nlm.nih.gov/pubmed/25609063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2588
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