Thermodynamics of Binding of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in the Rational Design of Potent and Isozyme-Selective Inhibitors of th...

Por Singh, Raushan K., Suzuki, Takayoshi, Mandal, Tanmay, Balsubramanian, Narayanaganesh, Haldar, Manas, Mueller, Dustin J., Strode, Jerrod A., Cook, Gregory, Mallik, Sanku, Srivastava, D. K.
Publicado no Biochemistry (2014)

The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma

Por Pokorny, Jenny L., Calligaris, David, Gupta, Shiv K., Iyekegbe, Dennis O., Mueller, Dustin, Bakken, Katrina K., Carlson, Brett L., Schroeder, Mark A., Evans, Debra L., Lou, Zhenkun, Decker, Paul A., Eckel-Passow, Jeanette E., Pucci, Vincenzo, Ma, Bennett, Shumway, Stuart D., Elmquist, William, Agar, Nathalie Y., Sarkaria, Jann N.
Publicado no Clin Cancer Res (2015)