Thermodynamics of Binding of Structurally Similar Ligands to Histone Deacetylase 8 Sheds Light on Challenges in the Rational Design of Potent and Isozyme-Selective Inhibitors of the Enzyme

[Image: see text] Among the different histone deacetylase (HDAC) isozymes, HDAC8 is the most highly malleable enzyme, and it exhibits the potential to accommodate structurally diverse ligands (albeit with moderate binding affinities) in its active site pocket. To probe the molecular basis of this fe...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Singh, Raushan K., Suzuki, Takayoshi, Mandal, Tanmay, Balsubramanian, Narayanaganesh, Haldar, Manas, Mueller, Dustin J., Strode, Jerrod A., Cook, Gregory, Mallik, Sanku, Srivastava, D. K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263425/
https://ncbi.nlm.nih.gov/pubmed/25407689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500711x
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