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Coumarin-SAHA as a Fluorescent Probe for Determining Binding Affinities and Off-Rates of Histone Deacetylase Inhibitors
Histone Deacetylases (HDACs) are intimately involved in the epigenetic regulation, and thus are one of the key therapeutic targets for cancer, and two HDAC inhibitors, namely suberoylanilide hydroxamic acid (SAHA) and romidepsin have been recently approved for the cancer treatment. Since the screeni...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2980575/ https://ncbi.nlm.nih.gov/pubmed/20816742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2010.08.040 |
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