Insight into the Cooperation of P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) at the Blood-Brain Barrier: A Case Study Examining Sorafenib Efflux Clearance

Por Agarwal, Sagar, Elmquist, William F.
Publicado em 2012

“INVESTIGATION OF THE MICELLAR EFFECT OF PLURONIC P85 ON P-GLYCOPROTEIN INHIBITION: CELL ACCUMULATION AND EQUILIBRIUM DIALYSIS STUDIES”

Por SHAIK, NAVEED, GIRI, NAGDEEP, ELMQUIST, WILLIAM F.
Publicado em 2009

Brain Distribution of Cediranib Is Limited by Active Efflux at the Blood-Brain Barrier

Por Wang, Tianli, Agarwal, Sagar, Elmquist, William F.
Publicado em 2012

Brain Distribution and Bioavailability of Elacridar after Different Routes of Administration in the Mouse

Por Sane, Ramola, Agarwal, Sagar, Elmquist, William F.
Publicado em 2012

Brain Efflux Index To Investigate the Influence of Active Efflux on Brain Distribution of Pemetrexed and Methotrexate

Por Li, Li, Agarwal, Sagar, Elmquist, William F.
Publicado em 2013

Interactions of Pluronic Block Copolymers on P-gp Efflux Activity: Experience With HIV-1 Protease Inhibitors

Por SHAIK, NAVEED, PAN, GUOYU, ELMQUIST, WILLIAM F.
Publicado no J Pharm Sci (2008)

Determination of Cediranib in Mouse Plasma and Brain Tissue Using High-Performance Liquid Chromatography-Mass Spectrometry

Por Wang, Tianli, Oberoi, Rajneet K., Elmquist, William F.
Publicado em 2011

Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability

Por Sane, Ramola, Mittapalli, Rajendar K., Elmquist, William F.
Publicado em 2013

Pharmacokinetic Assessment of Efflux Transport in Sunitinib Distribution to the Brain

Por Oberoi, Rajneet K., Mittapalli, Rajendar K., Elmquist, William F.
Publicado em 2013

OCT2 and MATE1 Provide Bi-directional Agmatine Transport

Por Winter, Tate N., Elmquist, William F., Fairbanks, Carolyn A.
Publicado no Mol Pharm (2010)

Utilizing transmembrane convection to enhance solute sampling and delivery by microdialysis: theory and in vitro validation

Por Bungay, Peter M., Wang, Tianli, Yang, Hua, Elmquist, William F.
Publicado em 2010

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

Por Agarwal, Sagar, Sane, Ramola, Ohlfest, John R., Elmquist, William F.
Publicado em 2011

Breast Cancer Resistance Protein and P-glycoprotein in Brain Cancer: Two Gatekeepers Team Up

Por Agarwal, Sagar, Hartz, Anika M.S., Elmquist, William F., Bauer, Björn
Publicado em 2011

Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on the Brain Distribution of a Novel BRAF Inhibitor: Vemurafenib (PLX4032)

Por Mittapalli, Rajendar K., Vaidhyanathan, Shruthi, Sane, Ramola, Elmquist, William F.
Publicado em 2012

Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System

Por Sane, Ramola, Agarwal, Sagar, Mittapalli, Rajendar K., Elmquist, William F.
Publicado em 2013

Bayesian Approach to Estimate AUC, Partition Coefficient and Drug Targeting Index for Studies with Serial Sacrifice Design

Por Wang, Tianli, Baron, Kyle, Zhong, Wei, Brundage, Richard, Elmquist, William
Publicado em 2013

Drug Delivery to Melanoma Brain Metastases: Can Current Challenges Lead to New Opportunities?

Por Gampa, Gautham, Vaidhyanathan, Shruthi, Sarkaria, Jann N., Elmquist, William F.
Publicado no Pharmacol Res (2017)

Mechanisms Limiting Distribution of the Threonine-Protein Kinase B-RaF(V600E) Inhibitor Dabrafenib to the Brain: Implications for the Treatment of Melanoma Brain Metastases

Por Mittapalli, Rajendar K., Vaidhyanathan, Shruthi, Dudek, Arkadiusz Z., Elmquist, William F.
Publicado em 2013

Sunitinib LC–MS/MS Assay in Mouse Plasma and Brain Tissue: Application in CNS Distribution Studies

Por Oberoi, Rajneet K., Mittapalli, Rajendar K., Fisher, James, Elmquist, William F.
Publicado em 2013

Factors Influencing the CNS Distribution of a Novel MEK-1/2 Inhibitor: Implications for Combination Therapy for Melanoma Brain Metastases

Por Vaidhyanathan, Shruthi, Mittapalli, Rajendar K., Sarkaria, Jann N., Elmquist, William F.
Publicado em 2014