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Mechanisms Limiting Distribution of the Threonine-Protein Kinase B-RaF(V600E) Inhibitor Dabrafenib to the Brain: Implications for the Treatment of Melanoma Brain Metastases

Brain metastases are a common cause of death in stage IV metastatic melanoma. Dabrafenib is a BRAF (gene encoding serine/threonine-protein kinase B-Raf) inhibitor that has been developed to selectively target the valine 600 to glutamic acid substitution (BRAF(V600E)), which is commonly found in meta...

詳細記述

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書誌詳細
主要な著者: Mittapalli, Rajendar K., Vaidhyanathan, Shruthi, Dudek, Arkadiusz Z., Elmquist, William F.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583506/
https://ncbi.nlm.nih.gov/pubmed/23249624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.201475
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